Neoprene (CR) is typically used as hose cover because of its flame-retardant property. It also exhibits decent ozone, aging and chemical resistance. It has good mechanical properties over a wide temperature range, typically as high as 121°C (250°F) and as low as -40°C (-40°F). Neoprene demonstrates good oil resistance and was originally intended to be an oil resistant replacement for natural rubber.

Neoprene is made from the polymerization of Chloroprene monomer, which was the first synthetic rubber developed commercially.